Design of a new electrocatalyst using assembling of nanoparticles could be considered the nowadays breakthrough in technology. An effective, environmentally friendly and reliable synthesis of nanoparticles is crucial. Electrochemical methods use a green reagent, i.e., electron and thus it is a promising alternative technique that can replace the conventional methods for preparation of nanoparticles. Depending on this, the current study depends on the possibility of preparing nanoparticles using electrochemical methods. Often, these methods are used in the electrochemical sensing of some neurotransmitters such as: Dopamine (DA), which plays an important role in the central nervous system, where its deficiency leads to several diseases, such as: schizophrenia and Parkinson's disease. So, it was monitored estimating the level of DA is an important requirement. But the problem in the presence of some interfering compounds, especially Ascorbic Acid (AA), which is found in large quantities in biological tissues along with DA, and the standard electrodes are ineffective to detect DA in the presence of AA. Consequently, the focus on modification of electrodes leads to enhanced sensitivity and improved selectivity for the detection of DA in the presence of AA and other interfering substances.